Cyclin-dependent kinase inhibitor p27(Kip1) expression in transitional cell carcinoma of renal pelvis and ureter

We examined the expression and significance of p27(Kip1) protein in 79 pati ents with transitional cell carcinoma of the renal pelvis and ureter. Immun ohistochemical staining of archival tissue specimens was done using a label ed streptavidin-biotin-peroxidase method. There was no significant associat ion between p27(Kip1) labeling index and histologic grade or pathologic sta ge. Patients with p27(Kip1) labeling indices of 27 or greater had more favo rable prognoses in comparison to those with p27(Kip1) labeling indices less than 27 (P < 0.01). Multivariate analysis indicated that p27(Kip1) had an independent predictive prognostic value (P < 0.05). The p27(Kip1) may be a novel prognostic marker for transitional cell carcinoma of the renal pelvis and ureter. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.