Generalized nodular dermatofibrosis and cystic renal disease in five German shepherd dogs

Cystic renal disease was recognized in four of five Germain shepherds with multiple skin nodules characterized by collagenous hyperplasia. One dog pre sented evidence of an abdominal mass, but no diagnosis was obtained. Renal cystadenocarcinomas was identified in two dogs. Uterine leiomyoma and granu losa cell tumor were diagnosed in one bitch. Pulmonary aetastasis (one dog) and renal failure (one dog) were observed. A dominant autosomal inheritanc e pattern for this syndrome is suggested. Dermatofibrosis in Germain shephe rds maya be indicative of internal neoplasia.