Chemoprevention of cancer

Authors
Citation
Mb. Sporn et N. Suh, Chemoprevention of cancer, CARCINOGENE, 21(3), 2000, pp. 525-530
Citations number
47
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CARCINOGENESIS
ISSN journal
01433334 → ACNP
Volume
21
Issue
3
Year of publication
2000
Pages
525 - 530
Database
ISI
SICI code
0143-3334(200003)21:3<525:COC>2.0.ZU;2-F
Abstract
In this short article, we review the conceptual basis for chemoprevention o f cancer, the proven clinical efficacy of this concept, and current trends to develop new chemo-preventive agents based on understanding of their mech anisms of action. Four classes of new agents, namely selective inhibitors o f cyclooxygenase-2, selective estrogen receptor modulators, rexinoids (reti noids that bind selectively to the receptors known as RXRs) and ligands for the peroxisome proliferator-activated receptor-gamma are discussed in deta il. The importance of developing totally new classes of chemopreventive age nts is stressed, with particular emphasis on the potential usefulness of ne w synthetic triterpenoids derived from naturally occurring molecules.