Studies of selective enrichment and recognized characteristics of paracetamol molecular template polymer

A molecular templated synthetic polymer as the receptor highly selective fo r paracetamol was prepared by a molecular imprinting technique, The selecti ve binding characteristics of the template polymer were evaluated by Scatch ard analysis and Ultraviolet spectrometry, The results showed that the acry lamide as the functional monomer was more better than methacrylic acid for paracetamol selectivity, and a class of the same binding sites which could specially bind paracetamol by the interaction of hydrogen bonding were form ed in the polymer and its dissociation constant was estimated to be 2. 25 X 10(-3) mol/L, The selective binding experiment for substrates indicated th at the polymer gave a higher affinity and selectivity for paracetamol, It i s possible to be a good adsorption and binding material in the selective en richment and determination of trace paracetamol in complex biosamples.