A 10-year follow-up study of renal transplant recipients treated with cyclosporine

Aim: In this report a 10-year follow-up of Japanese multicentre trial of re nal transplantation using cyclosporine is described. Material and methods: A total of 1,323 recipients, including 1,055 (79.7%) living donor (LD) tran splantations and 268 (20. 3%) non-heart-beating cadaveric donor (CD) transp lantations, were enrolled in the study. Results: Favorable results; graft s urvival at 1, 5 and 10 years were 95.8%, 80.9%, 56.8%, respectively, for LD , and 88.7%, 74.2%, 58.8%, respectively, even for CD, were obtained. No ser ious adverse reactions or complications were observed in this group of pati ents excepting 28 cases (2.0%) of malignant tumors. There were no cases of abnormality in 39 babies delivered during the term. Conclusion: We demonstr ate the interesting findings that graft survival of non-heart-beating CD ar e surprisingly as good as that of LD and the safety issues are almost equal to other available data in other countries.