Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Authors
Soderling, SH Beavo, JA
Citation
Sh. Soderling et Ja. Beavo, Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions, CURR OP CEL, 12(2), 2000, pp. 174-179
Citations number
41
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
174 - 179
Database
ISI
SICI code
0955-0674(200004)12:2<174:ROCACS>2.0.ZU;2-#
Abstract
The past eighteen months have provided much progress in the cyclic nucleoti de phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered and characterized. In addition, several new highly specific PDE inhibitors have been developed and approved for clinical use. Finally, new strategies have been employed to determine PDE function in model systems i ncluding the use of antisense oligonucleotide and disruption techniques.