A-kinase anchoring proteins: protein kinase A and beyond

Authors
Edwards, AS Scott, JD
Citation
As. Edwards et Jd. Scott, A-kinase anchoring proteins: protein kinase A and beyond, CURR OP CEL, 12(2), 2000, pp. 217-221
Citations number
40
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
217 - 221
Database
ISI
SICI code
0955-0674(200004)12:2<217:AAPPKA>2.0.ZU;2-N
Abstract
Compartmentalization of kinases and phosphatases is a key determinant in th e specificity of second messenger mediated signaling events. Localization o f the cAMP-dependent protein kinase (PKA) and other signaling enzymes is me diated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particul arly in the field of the functional consequences of PKA anchoring.