Effects of antiadhesive agents on the healing of intestinal anastomosis

PURPOSE: The effects of antiadhesive agents on the healing of intestinal an astomosis were investigated. METHODS: Eighty rats were divided into eight g roups. Colotomy and anastomosis were performed to ail rats. Saline solution (control), carboxymethylcellulose, aprotinin, verapamil, tenoxicam, cyclos porine, and dextran 70 were administered intraperitoneally. Vitamin E was a dministered intramuscularly. The rats were killed 15 days later. Anastomoti c healing was assessed by bursting pressure and the hydroxyproline content of the anastomotic tissues. The results were evaluated by Mann-Whitney U te st. RESULTS: The mean (+/- standard deviation) bursting pressures of carbox ymethylcellulose, cyclosporine, and aprotinin groups (108 +/- 6.73, 122.5 /- 14.39, and 127 +/- 20.23, respectively) were significantly lower than th ose of the control group (234 +/- 6.19). The mean level of hydroxyproline i n the anastomotic tissues was significantly lower in the carboxymethylcellu lose and cyclosporine groups (8.92 +/- 0.6 and 8.32 +/- 0.63) than that in the control group (16.33 +/- 0.68). CONCLUSION: These findings indicate tha t carboxymethylcellulose and cyclosporine had adverse effects on intestinal anastomosis in rats.