CHEMICAL AND BIOLOGICAL EVALUATION OF THE EFFECT OF PLANT-EXTRACTS AGAINST PLASMODIUM-BERGHEI

Extracts from thirteen species of plants were evaluated by ''in vivo'' antimalarial test against Plasmodium berghei effects. Significant act ivities were observed in the ethyl acetate and aqueous extracts, elabo rated of Cedrela tonduzii leaves, Trichilia havanensis and Trichilia a mericana barks, Neurolaena lobata and Gliricidia sepium leaves and Dur anta repens fruits. Compounds identified include flavonoids, coumarins , mellilotic acid and iridoids which some kind of biodinamic activity has previously been reported. The flavone quercetin 1 purified from C. tonduzii gave strong antimalarial activity, however, its respective g licosides (quercetin 3-glucoside 2 y robinine 7) showed little signifi cant activity.