Oxygen administration is one of the most important modalities of therapy fo
r a patient with hypoxaemia to prevent death and disability from common con
ditions such as acute lower respiratory tract infections. Oxygen needs to b
e available at all times in hospitals, however, it is tod expensive for man
y developing countries. There is little information for health professional
s regarding indications for initiating oxygen therapy, selecting appropriat
e method of oxygen administration and deciding on the source for oxygen. A
review of the literature using medline citations and cross references from
published articles and other manuscripts was made. The review described the
two main sources of oxygen for small hospital-cylinders and oxygen concent
rators and their advantages and disadvantages. It also look-ed at the evide
nces for clinical indications to initiate and discontinue oxygen therapy. S
tudies on efficient and safe methods of administration of oxygen were revie
wed as well. The review concluded that oxygen may be administered in childr
en with cyanosis, chest indrawing, inability to drink or breastfeed, tachyp
nea with-respiratory rate above 70/minute or in a child who develops restle
ssness and improves on oxygen. The initial capital cost-of concentrators is
high but the running cost is low and it does not re(require transport whil
e oxygen cylinders are expensive to transport and need continuous refilling
. The safest method of oxygen administration are the prongs followed by the
nasal catheters.