Primary gastric lymphoma associated with human T-cell leukaemia virus I

We herein report a case of primary gastric lymphoma with reference to human T-cell leukaemia virus type I. A 65-year-old male was admitted to our hosp ital for emergency treatment of abdominal pain and haematemesis, Upper gast rointestinal endoscopy on admission revealed a disintegrated tumour with bl eeding in the cardia. Total gastrectomy with distal pancreatomy and splenec tomy was performed. The patient soon fell into cachexic condition due to ea rly recurrence of abdominal lymph nodes and a rapid increase of the tumour, and died 80 days after operation. The pathological diagnosis was non-Hodgk in's lymphoma with diffuse large cell type and T-cell lineage. The patient was serologically positive for human T-cell leukaemia virus type I (HTLV-I) antibody, Southern blot analysis on the resected tumour tissue showed a mo noclonal integration of HTLV-I pro-viral DNA. These results confirmed the c urrent case to be primary adult T-cell leukaemia/lymphoma of the stomach. E ur J Gastroenterol Hepatol 12:357-360 (C) 2000 Lippincott Williams & Wilkin s.