A. Tedeschi et al., Treatment of chronic myeloid leukemia in the blastic phase with fludarabine, cytosine arabinoside and G-CSF (FLAG), EUR J HAEMA, 64(3), 2000, pp. 182-187
The present study was undertaken to evaluate the efficacy of the associatio
n of fludarabine plus Ara-C and G-CSF (FLAG) in the treatment of 15 patient
s with chronic myeloid leukemia in the blastic phase (CML-BP). Patients ach
ieving a partial remission (PR) after the first course received a second FL
AG. Complete remission (CR) was consolidated with another FLAG regimen. Pat
ients were then submitted to an individualized program of treatment dependi
ng on age and suitable donors. Overall seven patients achieved CR (46.7%),
three (20%) showed a primary resistant disease, while three (20%) died duri
ng remission induction therapy. Five of them received a consolidation thera
py; in two cases further treatment was not performed because of severe toxi
city. Median overall survival and disease-free survival were of 7.5 and 4.5
months, respectively. FLAG proved to be effective in achieving a high CR r
ate in patients with CML-BP. Median overall survival and disease-free survi
val were not significantly improved compared to previous studies. Neverthel
ess, the treatment was well tolerated even in a group of heavily pretreated
patients, allowing further transplantation opportunities in younger patien
ts.