R. Smolarczyk et al., The biochemical functions of the renal tubules and glomeruli in the courseof intrahepatic cholestasis in pregnancy, EUR J OB GY, 89(1), 2000, pp. 35-39
Citations number
20
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Biochemical functions of kidney glomeruli and tubules were estimated in pre
gnancy complicated by cholestasis. The investigated group consisted of 72 w
omen with pregnancy complicated by cholestasis and 30 healthy pregnant pati
ents as a control group. Biochemical assays were performed for the deaminat
ion of amino acids, carbonic acid dissociation and creatinine metabolism. S
tatistical analysis was carried out using the t-test and P<0.05 was conside
red to be significant. In diurnal urine samples collected from pregnant pat
ients with cholestasis, decreased concentrations of NH4+ (42.0+/-8.9 versus
50.3+/-7.6 mmol/24 h), H+ (19.0+/-7.0 versus 25.0+/-5.0 mmol/24 h), creati
nine (1.15+/-0.2 versus 1.43+/-0.3 mmol/24 h) as well as lower levels of cr
eatinine clearance (89.0+/-23.0 versus 135.0+/-30.0 ml/min) and normal leve
ls of potassium and sodium were observed. Serum creatinine and uric acid co
ncentrations were elevated (86.6+/-7.07 versus 66.3+/-4.42 mu mol/l and 32.
1+/-8.3 versus 19.0+/-3.57 mu mol/l). Diurnal urine volume was lower in pat
ients with cholestasis than in the control group (995+/-313 versus 1264+/-4
26 ml/24 h). Disturbances of biochemical functions of kidney glomeruli and
tubules, regarding creatinine metabolism and deamination of amino acids, an
d dissociation of carbonic acid, were seen in patients with cholestasis dur
ing pregnancy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.