The challenges of specifying a complex and individualized treatment model a
nd measuring fidelity thereto are described, using multisystemic therapy (M
ST) as an example. Relations between therapist adherence to MST principles
and instrumental and ultimate outcome variables are examined, as are relati
ons between clinical supervision and therapist adherence. The findings prov
ide modest support for the associations between MST adherence measures and
instrumental and ultimate outcomes. Results also show that adherence can be
altered when clinical supervision and adherence monitoring procedures are
fortified. The modest associations between adherence measures and youth out
comes argue for further refinement and validation of the MST adherence meas
ure, especially in light of the well-established effectiveness of MST with
challenging clinical populations and the increasing dissemination of MST pr
ograms.