Bacterial Mn2+ oxidizing systems and multicopper oxidases: An overview of mechanisms and functions

Manganese is oxidized by a wide variety of bacteria. The current state of k nowledge on mechanisms and functions of Mn2+ oxidation in two strains of Ps eudomonas putida, in Leptothrix discophora SS-1, and in Bacillus sp. strain SG-1 is reviewed. In all three species, proteins bearing resemblance to mu lticopper oxidases appear to be involved in the oxidation process. A short description of the classification of Cu centers is followed by a more detai led review of properties and postulated functions of some well-known multic opper oxidases. Finally, suggestions are made for future research to assess the potential role of multicopper oxidases in bacterial Mn2+ oxidation.