Relationships among squamate families have classically been difficult to es
tablish, with morphological characters being interpreted to give many diffe
rent topologies. Here we combine new C-mos nuclear DNA sequence data with t
hose already published to assess relationships of 19 families within the Sq
uamata. Monophyly of all the families examined is upheld. Many relationship
s between families are estimated, although it appears there may have been r
apid cladogenesis associated with the origins of the Squamata.