Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an eta(1)-coordination mode

Authors
Nishino, S Kunita, M Kani, Y Ohba, S Matsushima, H Tokii, T Nishida, Y
Citation
S. Nishino et al., Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an eta(1)-coordination mode, INORG CH C, 3(3), 2000, pp. 145-148
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY COMMUNICATIONS
ISSN journal
13877003 → ACNP
Volume
3
Issue
3
Year of publication
2000
Pages
145 - 148
Database
ISI
SICI code
1387-7003(200003)3:3<145:COTCBO>2.0.ZU;2-8
Abstract
We have obtained clear evidence that a copper(II)-peroxide adduct with an e ta(1)-coordination mode can cleave the C-N bond of a peptide group and hydr oxylate the alkyl group nearby; this may provide helpful information for el ucidation of the reaction mechanism of PAM, peptidylglycine alpha-amidating monooxygenase. (C) 2000 Elsevier Science S.A. All rights reserved.