Adamantylamide dipeptide stimulates hematopoiesis and increases survival in irradiated mice

It has been demonstrated that the synthetic immunostimulatory compound, ada mantylamide dipeptide (AdDP) produces hematopoiesis-stimulating effects in mice exposed to sublethal doses of ionizing radiation and increases surviva l in experimental animals irradiated with a lethal dose. These findings mig ht suggest contingent extension of clinical indications for the administrat ion of AdDP for the conditions of hematopoietic suppression, especially in oncology. (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.