Expression of hnRNP A2/B1 proteins in human cancer cell lines

The overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is recently reported informative as a marker of lung cancer for early dete ction. To examine whether the expression of the proteins is specific for lu ng cancer, immunological analyses were performed both in lung and non-lung cancer cell lines. In immunostaining and Western blotting, the expression o f A2/B1 was observed not only in the lung cancer cells but also in non-lung cancer cells. The expression of hnRNP A2/B1 is not specific for lung cance r and quantitative determination of A2/B1 is required to elucidate their si gnificance in carcinogenesis.