Determination of optimal combination of surfactants in creams using rheology measurements

Citation
M. Korhonen et al., Determination of optimal combination of surfactants in creams using rheology measurements, INT J PHARM, 197(1-2), 2000, pp. 143-151
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
197
Issue
1-2
Year of publication
2000
Pages
143 - 151
Database
ISI
SICI code
0378-5173(20000320)197:1-2<143:DOOCOS>2.0.ZU;2-P
Abstract
The effect of surfactant on the rheological properties of some cream formul ations was studied. Two surfactants from two different series were combined to determine the combination which yielded the most viscoelastic structure for creams. The surfactants were the soybean derivatives soya sterol, poly ethylene glycol 10 soya sterol and polyethylene glycol 25 soya sterol and t he sorbitol derivatives sorbitan monooleate and sorbitan trioleate. The rhe ological properties of the creams were studied using oscillation stress swe ep, oscillation frequency sweep and viscosity tests. Droplet size distribut ion and conductivity of the creams were also determined. The combination po lyethylene glycol 10 soya sterol and sorbitan trioleate yielded the most vi scoelastic structure with linearly viscoelastic behaviour. (C) 2000 Elsevie r Science B.V. All rights reserved.