The use of some ingredients for microemulsion preparation containing retinol and its esters

A study of microemulsions with retinol and its eaters. Physical properties of w/o and o/w microemulsions containing Tween 60, Tween 80, Epicurone 135 (soy bean lecithin) as surfactants, n-butanol, triacetin. propylene glycol as cosurfactants were examined. The drug-containing systems were characteri sed in regard to their ophthalmic parameters. Physiologically well-tolerate d and physically stable multiple-components were developed. The concentrati ons of surfactants and cosurfactants which are necessary to form stable sys tems were evaluated. The values of the following parameters - refractive in dex, viscosity, pH value, osmotic tension, obtained in the study, proved su itable for the purpose and the preparations were physiologically tolerated, the use of microemulsions as potential drug delivery systems for ocular ad ministration has been discussed. The influence of retinol and its eaters on the physical parameters the preparation was investigated. Microemulsion st ored at 20 degrees C up to 6 months showed no significant physical changes. (C) 2000 Published by Elsevier Science B.V. All rights reserved.