Nanosuspensions of poorly soluble drugs - reproducibility of small scale production

The major problem of many newly developed pharmaceutical drugs is their poo r solubility in water and simultaneously in organic media. To solve these p roblems formulation as nanosuspensions is an attractive alternative. During the drug development process screening for an optimal formulation by homog enisation is essential. Time and cost effective production in an initial ph ase of R&D can be conducted on lab scale by using the Micron Lab 40 in its discontinuous version. In this report reproducibility of small scale produc tion parameters (particle size, size distribution, content of microparticle s) was exemplary studied for the drug RMKP22. (C) 2000 Elsevier Science B.V . All rights reserved.