Influence of high pressure homogenisation equipment on nanodispersions characteristics

In this study a comparison of the influence of the homogenising equipment s upplied by different manufacturers on the quality of the lipid nanodispersi ons is given. An Avestin EmulsiFlex-B3 (B3) and APV Micron Lab 40 (LAB 40) were used for high pressure homogenisation. Particle size and particle size distribution were chosen as qualify parameters. The influence of different process parameters was evaluated. The: two homogenisers were compared in t heir qualify of nanoparticles-production by hot and cold homogenisation tec hnique and in processing nanoemulsions. Working with the B3 appeared as use ful for preformulation studies and processing of expensive or rare drugs an d excipients. This first scaling up within laboratory scale is evaluated an d the problems and remarkable aspects working with the B3 are pointed out. (C) 2000 Elsevier Science B.V. All rights reserved.