Influence of different parameters on reconstitution of lyophilized SLN

Drug-loaded solid lipid nanoparticles (SLN) suitable for parenteral adminis tration were freeze-dried. The lipid matrix Imwitor 900 (concentration, 2.5 %) was stabilized with Lipoid E 80 and sodium glycocholate. The influence o f different parameters of lyophilization like the protective effect of cryo protectants, freezing velocity, and thermal treatment was investigated. The results of this study demonstrate that, by optimizing critical process par ameters, i.v.-injectable SLN-dispersions can be freeze-dried, preserving th eir small particle size. (C) 2000 Elsevier Science B.V. All rights reserved .