T. Hartman et al., Radiation doses to the cell nucleus in single cells and cells in micrometastases in targeted therapy with I-131 labeled ligands or antibodies, INT J RAD O, 46(4), 2000, pp. 1025-1036
Citations number
16
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: The aim of this study was to theoretically investigate how the rad
iation dose to cell nuclei depends on the subcellular position of I-131. Th
e influence of the size of the cells and crossfire irradiation in clusters
of cells was also studied.
Methods and Material: Using data describing the dose rate around a point so
urce of I-131, We calculated the dose distributions inside and around cell
models of different sizes. The assumed positions of I-131 were on the cellu
lar or nuclear membrane, in the cytoplasm, in the nucleus, or spread in the
whole cell. The mean doses to the nucleus of the targeted cell and to the
nuclei of its neighbors were calculated using the dose distributions.
Results: The dose distributions inside a single targeted cell showed very d
ifferent distribution profiles depending on the subcellular position of the
I-131. Targeting the nucleus instead of the cellular membrane could increa
se the dose to the nucleus 10-fold. Crossfire irradiation can be the major
contributor to the nuclear dose in clusters of more than six cells.
Conclusions: Dosimetry without microscopic considerations is inadequate for
targeted radionuclide therapy of disseminated or clustering tumor cells ex
posed to I-131. Therapeutic doses could be achieved, even in single cells,
when I-131 was positioned near, or inside the cell nucleus, or when the clu
sters were large enough. (C) 2000 Elsevier Science Inc.