G. Sersa et al., Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors, INT J RAD O, 46(4), 2000, pp. 1037-1041
Citations number
39
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: To evaluate whether a local drug delivery method, i.e., electropor
ation of tumors, increases the radiosensitizing effect of cisplatin,
Methods and Materials: Subcutaneous Ehrlich-Lettre ascites (EAT) tumors in
CBA mice were treated either by cisplatin, electric pulses, or ionizing rad
iation. In electrochemotherapy protocol, electric pulses were given to the
tumor 3 min after intravenous injection of cisplatin, The interval between
electrochemotherapy and irradiation was 20 min. Treatment effectiveness was
evaluated by tumor growth delay and local tumor curability.
Results: Electrochemotherapy of EAT tumors proved to be effective treatment
, resulting in 12% tumor cures, whereas treatment with cisplatin or electri
c pulses alone did not yield any tumor cures. As expected, injection of cis
platin 20 min prior to irradiation, increased radioresponse of tumors from
27% to 73% tumor cures. Electroporation of tumors also increased radiation
response of tumors to 54% tumor cures. Electrochemotherapy given prior to i
rradiation increased radioresponsiveness of tumors, resulting in 92% tumor
cures.
Conclusions: This study shows that delivery of cisplatin into the cells by
electroporation of tumors increases the radiosensitizing effect of cisplati
n, However, some effect may also be ascribed to application of electric pul
ses to the tumors that in our study also predisposed tumor cells to radiati
on damage. (C) 2000 Elsevier Science Inc.