Influence of estracorporeal irradiation on the reintegration of autologousgrafts of bone and joint - Study in a canine model

We studied the effects of irradiation on the reintegration of autologous os teoarticular grafts over a period of 24 weeks in a canine model. In 16 foxh ounds the medial femoral condyle was resected, irradiated and immediately r eplanted. In the control group resection and replantation were performed wi thout irradiation. Reintegration was assessed by macroscopic analysis, hist ology, radiography and gait analysis. Reintegration was equal at 12 weeks, but significantly inferior in the irra diated group after 24 weeks with delayed bone remodelling, The articular ca rtilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was i nferior in the treated group.