Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones

Authors
Katritzky, AR Serdyuk, L Chassaing, C Toader, D Wang, XJ Forood, B Flatt, B Sun, CC Vo, K
Citation
Ar. Katritzky et al., Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones, J COMB CHEM, 2(2), 2000, pp. 182-185
Citations number
24
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
2
Issue
2
Year of publication
2000
Pages
182 - 185
Database
ISI
SICI code
1520-4766(200003/04)2:2<182:SO2A2A>2.0.ZU;2-J
Abstract
Several substituted 2- and 4-hydroxyacetophenones are linked to Wang resin via a modified Mitsunobu protocol. These resin-bound acetophenones are cond ensed with aromatic aldehydes, and the resulting chalcones 5 are used for t he synthesis of 2-dialkylamino- (9a-d) and 2-alkylamino-4,6-diarylpyridines (11a-f), and 2-alkyl-4,6-diaryl- (14a) and 2,4,6-triarylpyrimidines (14b,c ) in a manner suitable for combinatorial applications.