Several new techniques for carpal tunnel syndrome diagnosis have been devel
oped in the last few years. This work tests a technique that compares the d
istal motor latency of the median nerve to the second lumbrical muscle (2L)
with the distal motor latency of the ulnar nerve to the interossei muscle
(INT). Results from 40 normal hands give the superior limit of the normal d
ifference (2L-INT) as 0.26 ms ((x) over bar + SD). In 55 hands with differe
nt levels of carpal tunnel syndrome, this new technique was more sensitive
and accurate than the conventional test which uses the distal motor latency
of the median nerve to the abductor pollicis brevis muscle (APB), especial
ly in the less severe cases. With the absence of the compound muscle action
potentials of the APE muscle caused by severe thenar atrophy, it is much e
asier to obtain the potential from the 2L muscle. We concluded that this is
a sensitive, simple, rapid, and non-invasive new technique, and therefore,
it should be incorporated as part of the routine ENMG procedures for carpa
l tunnel syndrome diagnosis. (C) 2000 Elsevier Science Ltd. All rights rese
rved.