A study involving venlafaxine overdoses: Comparison of fatal and therapeutic concentrations in postmortem specimens

Authors
Jaffe, PD Batziris, HP van der Hoeven, P DeSilva, D Path, D McIntyre, IM
Citation
Pd. Jaffe et al., A study involving venlafaxine overdoses: Comparison of fatal and therapeutic concentrations in postmortem specimens, J FOREN SCI, 44(1), 1999, pp. 193-196
Citations number
15
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
JOURNAL OF FORENSIC SCIENCES
ISSN journal
00221198 → ACNP
Volume
44
Issue
1
Year of publication
1999
Pages
193 - 196
Database
ISI
SICI code
0022-1198(199901)44:1<193:ASIVOC>2.0.ZU;2-8
Abstract
The distribution and redistribution of venlafaxine were investigated in two overdoses and several cases involving the therapeutic use of venlafaxine. Blood, liver, bile vitreous humor, urine and gastric contents were analyzed using high performance liquid chromatography with ultraviolet detection. B lood concentrations of venlafaxine in the two overdose cases were 53 mg/L a nd 78 mg/L. Comparison of venlafaxine concentrations in blood samples taken at different times after death revealed increases in concentrations over r ime, suggesting the possible postmortem redistribution of venlafaxine.