Mj. Alcorn et al., The number of CD34(+) cells mobilized into the peripheral blood can predict the quality of subsequent collections, J HEMATH ST, 9(1), 2000, pp. 89-93
Citations number
16
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
PBPC were mobilized using a variety of chemotherapy regimens plus G-CSF in
a group of 126 consecutive patients. Data are presented that show a close c
orrelation between the number of CD34(+) cells mobilized into the periphera
l blood (PB) and the number of CD34(+) cells subsequently collected by leuk
apheresis (R = 0.904), On the basis of this correlation, a regression formu
la was calculated that could give an estimate of the total number of CD34() cells likely to be collected by leukapheresis from a given number of CD34
(+) cells per microliter PB, An easy-to-read table has been compiled to sho
w how this type of analysis can be applied to predict the likely dose of CD
34(+) cells that will be obtained by leukapheresis over a wide range of pat
ient weights.