Allelic loss at the D9S171 focus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma

Papillary renal cell carcinomas (RCCs) have characteristic clinical and mor phological features that separate them from the more common clear cell RCCs , The details of the molecular changes in papillary RCC progression are not well understood. In this study, four highly polymorphic microsatellite mar kers [D9S970 (9p12-9p13), D9S171 (9p13), D9S1748 (9p21) and D9S156 (9p21)] were used to determine the frequency and prognostic significance of 9p dele tions in 37 papillary RCCs, Allelic deletions were detected in eight cases (22%), The highest rate of loss of heterozygosity (LOH) was observed in 6 o f 29 informative patients (21%) at the D9S171 locus on 9p13, Only two patie nts displayed allelic loss at D9S1748, which resides in close proximity to p16(INK4). TWO Of 24 informative papillary RCCs (8%) showed LOH for D9S970, LOH at D9S171 (9p13) was associated with short patient survival (p = 0.008 ), independently of tumour grade and stage, These data suggest a tumour sup pressor gene centromeric to 9p21 that may contribute to papillary RCC progr ession. Copyright (C) 2000 John Wiley & Sons, Ltd.