Overwhelming septic cavernous sinus thrombosis in a woman after combination of high-dose steroid and intravenous cyclophosphamide therapy for lupus nephritis

There are many treatment methods for lupus nephritis. including high-dose s teroids, pulse methylprednisolone. and cyclophosphamide therapy. In cycloph osphamide therapy, there can be some side effects such as nausea. vomiting, and infection. We report on a case receiving a combination of high dose st eroid and intravenous cyclophosphamide. Following this, she developed a fev er and a protruding right eye, and septic cavernous sinus thrombosis was di agnosed. This complication had never been reponed in a patient with systemi c lupus erythematosus, and related literature is reviewed.