Streptomyces sp Z-11-6, a novel producer of extracellular L-glutamate oxidase

Glutamate oxidase activity was studied in 1254 Streptomyces strains isolate d from the zonal soils of various regions of Russia and other countries. Se ven strains proved to be producers of extracellular L-glutamate oxidase. Th e most active producer strain was identified, and the conditions of enzyme biosynthesis were optimized. A multistep mutagenesis-selection procedure al lowed a genetically stable strain, Streptomyces sp. Z-11-6, to be obtained, whose glutamate oxidase activity was 40 times higher than that of the orig inal natural isolate.