Polymorphism of the D6S2414 marker of the HLA locus 6p21.31 and genetic predisposition to Graves' disease in muscovites

Authors
Chistyakov, DA Savost'yanov, KV Turakulov, RA Petunina, NA Trukhina, LV Kudinova, AV Balabolkin, MI Nosikov, VV
Citation
Da. Chistyakov et al., Polymorphism of the D6S2414 marker of the HLA locus 6p21.31 and genetic predisposition to Graves' disease in muscovites, MOL BIOL, 34(1), 2000, pp. 18-21
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
34
Issue
1
Year of publication
2000
Pages
18 - 21
Database
ISI
SICI code
0026-8933(200001/02)34:1<18:POTDMO>2.0.ZU;2-0
Abstract
The polymorphism of the D6S2414 microsatellite located in the HLA locus on chromosome 6p21.31 was studied in healthy individuals (N = 153) and patient s with diffuse toxic goiter (DTG, N = 78) from Moscow. Nine alleles ranging from 160 to 192 nt and containing 5 to 13 tetranucleotide repeats were fou nd. The frequencies of alleles 7 and 8 were significantly higher and those of alleles 5, 6, and 12 were lower in DTG patients than in controls. The tw o groups also significantly differed in the frequencies of seven genotypes. This suggested the association of D6S2414 and its vicinity with DTG in the Moscow population.