Secondary structure of the 5 ' region of the human multiple drug resistance gene mRNA

Authors
Kostenko, EV Beabealashvilli, RS Vlassov, VV Zenkova, MA
Citation
Ev. Kostenko et al., Secondary structure of the 5 ' region of the human multiple drug resistance gene mRNA, MOL BIOL, 34(1), 2000, pp. 56-65
Citations number
34
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
34
Issue
1
Year of publication
2000
Pages
56 - 65
Database
ISI
SICI code
0026-8933(200001/02)34:1<56:SSOT5'>2.0.ZU;2-L
Abstract
The secondary structure of a 678-nt 5' fragment of mRNA of the human multip le drug resistance (MDR) gene mdr1 was analyzed in order to identify optima l targets for antisense oligonucleotides. The data of RNA structure probing with RNases ONE, T1, and V1 and computer simulation suggested a three-doma in structure of the region under study. The accessible sites thus predicted efficiently hybridized with complementary oligonucleotides.