Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice

The organotin compounds dibutyltin (DBTC) and diphenyltin dichlorides (DPTC ) were tested for trypanocidal activity, on a Trypanosoma brucei-infected m ice model. At a dose of mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, sp leen, kidney, cerebrospinal fluid and blood from the mice considered cured, showed a few cases of relapse. The LD50 of DBTC and DPTC are 90 mg/kg and 75 mg/kg respectively.