In this study the distribution of the various antigenic types of canine par
vovirus in Switzerland, Austria, and Germany was investigated. From 14 samp
les from Switzerland, 35 samples from Austria, and 82 samples from Germany
exclusively the new antigenic types CPV-2a and CPV-2b were isolated. Most o
f these isolates had a Ser-Val mutation at amino acid 297, which was shown
to be prevalent in recent CPV isolates from various parts of the world. The
se findings are discussed with regard to the use of modified live virus vac
cines.