A new transformation of 2H-pyran-2-one ring: First synthesis of pyridazino[4,3-c] azepines and their oxidation with thallium(III) nitrate or copper(II) acetate

Authors
Kafka, S Trebse, P Polanc, S Kocevar, M
Citation
S. Kafka et al., A new transformation of 2H-pyran-2-one ring: First synthesis of pyridazino[4,3-c] azepines and their oxidation with thallium(III) nitrate or copper(II) acetate, SYNLETT, (2), 2000, pp. 254-256
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
2
Year of publication
2000
Pages
254 - 256
Database
ISI
SICI code
0936-5214(200002):2<254:ANTO2R>2.0.ZU;2-W
Abstract
A novel reaction starting from pyrano[3,2-c]azepines 1 and hydrazine hydrat e was used for the preparation of the first derivatives of pyridazino[4,3-c ]azepines 2. They were further oxidised by thallium(III) nitrate trihydrate (TTN) or copper(II) acetate hydrate (CuDA) to give aromatised fused pyrida zine derivatives 5 also containing an ester function formed from the carboh ydrazide moiety.