Chemical synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate, thekey intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis

Authors
Hoeffler, JF Pale-Grosdemange, C Rohmer, M
Citation
Jf. Hoeffler et al., Chemical synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate, thekey intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis, TETRAHEDRON, 56(11), 2000, pp. 1485-1489
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
11
Year of publication
2000
Pages
1485 - 1489
Database
ISI
SICI code
0040-4020(20000310)56:11<1485:CSOE24>2.0.ZU;2-E
Abstract
Optically pure 2-C-methyl-D-erythritol 4-phosphate, a key intermediate in t he mevalonate-independent route for isoprenoid biosynthesis, is convenientl y synthesized from 1,2-O-isopropylidene-alpha-D-xylofuranose, including the possibility of radiolabeling of this substrate. (C) 2000 Elsevier Science Ltd. All rights reserved.