A practical stereoselective synthesis of both enantiomers of threo- and erythro-beta-hydroxy norvaline from (S)-serine derivatives

Authors
Andres, JM de Elena, N Pedrosa, R
Citation
Jm. Andres et al., A practical stereoselective synthesis of both enantiomers of threo- and erythro-beta-hydroxy norvaline from (S)-serine derivatives, TETRAHEDRON, 56(11), 2000, pp. 1523-1531
Citations number
45
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
11
Year of publication
2000
Pages
1523 - 1531
Database
ISI
SICI code
0040-4020(20000310)56:11<1523:APSSOB>2.0.ZU;2-T
Abstract
The four enantiopure diastereoisomers of beta-hydroxy norvaline have been p repared from L-serine in moderate chemical yield. The method is based on th e diastereoselective addition of different organometallics to easily access ible serinal derivatives. (C) 2000 Elsevier Science Ltd. All rights reserve d.