Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol

Authors
Maltais, R Berube, M Marion, O Labrecque, R Poirier, A
Citation
R. Maltais et al., Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol, TETRAHEDR L, 41(11), 2000, pp. 1691-1694
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
11
Year of publication
2000
Pages
1691 - 1694
Database
ISI
SICI code
0040-4039(20000311)41:11<1691:ECASSO>2.0.ZU;2-C
Abstract
High-yield coupling of steroidal hindered ketones onto polymer-bound glycer ol by an efficient acetal exchange reaction is reported under mild conditio ns. A solid-phase model sequence of five steps is thereafter achieved to sy nthesize a steroidal ketone derivative having two levels of diversity in go od yield and purity. (C) 2000 Elsevier Science Ltd. All rights reserved.