Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors

Authors
Peixoto, C Laurin, P Klich, M Dupuis-Hamelin, C Mauvais, P Lassaigne, P Bonnefoy, A Musicki, B
Citation
C. Peixoto et al., Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors, TETRAHEDR L, 41(11), 2000, pp. 1741-1745
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
11
Year of publication
2000
Pages
1741 - 1745
Database
ISI
SICI code
0040-4039(20000311)41:11<1741:SOI2A1>2.0.ZU;2-M
Abstract
The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibit ors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory pot ency in negative supercoiling of relaxed DNA gyrase. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.