Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies

In neonates, one limitation of vaccination is its inhibition by maternal an tibodies. We show that piglets vaccinated intramuscularly once at birth wit h recombinant replication-defective adenoviruses developed comparable neutr alizing antibody response against pseudorabies virus, independently of the presence or absence of maternal antibodies, and were partially protected ag ainst challenge 16 weeks later. (C) 2000 Elsevier Science Ltd. All rights r eserved.