Low-molecular-weight heparin therapy for venous thromboembolism

Low-molecular-weight heparins, nowadays already widely used for the prevent ion of thromboembolism, have now also become available for the treatment of deep-vein thrombosis. This article should serve to explain the rationale f or this development and to demonstrate the clinically relevant advantages o f the use of low-molecular-weight heparins. After briefly describing the ch aracteristic properties of heparins the most relevant studies comparing the use of low-molecular-weight heparin versus unfractionated heparin for the treatment of thromboembolism are discussed. In conclusion, clinical trials suggest that low-molecular-weight heparins given subcutaneously can replace the hitherto standard intravenous application of unfractionated heparin in the initial treatment of deep-vein thrombosis, granting equal or even bett er efficacy and potentially lower rates of adverse side effects. Furthermor e, the simplicity of this therapeutic regime allows for treatment of patien ts at home, thus offering patients mobility and also reducing the cost of t reatment.