Low molecular weight dextran attenuates increase in extravascular lung water caused by ARDS

Citation
N. Yahagi et al., Low molecular weight dextran attenuates increase in extravascular lung water caused by ARDS, AM J EMER M, 18(2), 2000, pp. 180-183
Citations number
20
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
AMERICAN JOURNAL OF EMERGENCY MEDICINE
ISSN journal
07356757 → ACNP
Volume
18
Issue
2
Year of publication
2000
Pages
180 - 183
Database
ISI
SICI code
0735-6757(200003)18:2<180:LMWDAI>2.0.ZU;2-4
Abstract
We studied the effect of tow molecular weight dextran (mean molecular weigh t 40,000, Dextran 40; LMD) on the accumulation of extravascular lung water (EVLW), and also on hemodynamics and blood gases, in the oleic acid (OA)-in jured lung in pentobarbital anesthetized rats. Starting just before the OA injection (0.01 mL/kg via femoral vein), 10% LMD in lactated Ringer's solut ion was infused throughout the experiment (5 mL/kg/h) instead of lactated R inger's solution. OA caused acute lung injury leading to decreased oxygenat ion (PaO2: 87 +/- 11 mmHg versus central group 128 +/- 11) and an increased permeability of the alveolar-capillary membrane, as shown by increases in EVLW (4.89 +/- 0.54 versus control group 4.07 +/- 0.14), and albumin leakag e (0.043 +/- 0.015 versus control group 0.010 +/- 0.004). LMD protected aga inst the increase in EVLW (4.14 +/- 0.10) and the hypoxemia (112 +/- 19 mmH g), but it did not reduce the albumin leakage into the alveolar space (0.05 2 +/- 0.009). These data suggest that LMD may limit the fluid accumulation that is secondary to OA-induced lung injury. (Am J Emerg Med 2000;18:180-18 3, Copyright (C) 2000 by W.B. Saunders Company).