Antioxidant vitamins (provitamins) may protect against loss of lung functio
n over time. We studied the association between serum carotenoids (alpha-ca
rotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, and lutein
), alpha-tocopherol, and lung function among nonistitutionalized Dutch elde
rly age 65 to 85 yr (n = 528). Multiple linear regression analysis was perf
ormed with FEV1 or FVC as dependent variables and serum levels of antioxida
nts in quintiles as independent variables. We adjusted for age, gender, hei
ght, and pack-years of smoking. Subjects in the fifth quintile of serum bet
a-carotene had a 195 ml (95% confidence interval [95% CI]: 40 to 351 ml) hi
gher and those in the fifth quintile of alpha-carotene had a 257 ml (95% CI
: 99 to 414 ml) higher FEV1 compared with subjects in the first quintile of
these carotenoids. Significant (p < 0.05) positive trends were observed be
tween alpha-carotene beta-carotene, lycopene, and FEV1 and between alpha-ca
rotene, beta-carotene, and FVC. Subjects in the highest quintile of the oth
er carotenoids or alpha-tocopherol did not have significantly higher FEV1 o
r FVC compared with subjects in the first quintile of these antioxidants. I
n conclusion, this study shows that from the six major serum carotenoids an
d alpha-tocopherol studied, particularly alpha-carotene, beta-carotene, and
lycopene were positively associated with lung function in the elderly and
may be considered as candidates for further investigations.