Congeneric behavior in estimations of octanol-water partition coefficientsby micellar electrokinetic chromatography

Linear Solvation Energy Relationships (LSERs) are used to explain the conge neric behavior observed when using Micellar Electrokinetic Chromatography ( MEKC) to estimate the octanol-water partition coefficient scale of solute h ydrophobicity. Such studies provide useful insights about the nature of Sol ute interactions that are responsible for the sources of congeneric relatio nships between MEKC retention and log P-o/w. It was determined that solute dipolarity/polarizability and hydrogen-bonding character play the most impo rtant roles in the congeneric behavior observed for many surfactant systems . The individual dipolarity/polarizability and hydrogen-bonding contributio ns to the free energy of transfer were also investigated.