Plasma lipid concentrations during episodic occupational stress

The possibility that stress affects plasma lipid concentrations has been th e subject of recent investigation but the findings are equivocal in nonlabo ratory settings. To determine whether psychological stress contributes to v ariability in plasma lipid concentrations and concomitant changes in health behaviors, the effect of increased work load on plasma lipids and apolipop roteins was examined in 173 lawyers. Plasma cholesterol, triglyceride, and apolipoprotein concentrations were studied during periods of high work load (corresponding to impending tax deadlines) and during periods of usual wor k load. Self-reports of stress, work load, and time pressure, and cortisol, blood pressure, and heart rate were measured to verify that impending dead lines were associated with increased stress levels. Health behaviors which may affect plasma lipoprotein concentrations, including dietary intake and exercise, were also examined. High work load was accompanied by increases i n self-reported work load among lawyers most directly affected by the impen ding deadlines. Plasma apolipoprotein B and triglycerides increased during periods of high work load (M = 1.9 mg/dL, SD = 10.1 and M = 5.3, SD = 34.4, respectively). No changes in dietary intake and exercise were observed. Ps ychological stress (high work load) is associated with potentially atheroge nic changes in plasma lipid concentrations. While the lipoprotein effect of this short-term work stress is small, the effects of longer-term stress on multiple risk factors including triglycerides and apolipoprotein B could h ave significance for the development of coronary artery disease.