Age does not influence early and late tumor-related outcome for bronchogenic carcinoma

Background. The influence of age on early and late outcome after surgical r esection of bronchogenic carcinoma is unknown. In an attempt to clarify thi s issue, we reviewed the outcome of 212 consecutive patients with primary l ung cancer who had surgical treatment for bronchogenic carcinoma. Methods. Ninety-two patients were younger than 50 years (group 1), and 120 patients were older than 70 years of age (group 2). Squamous cell carcinoma and adenocarcinoma were the most common histologic types in both groups. A ccording to the new international staging classification, a similar proport ion of stage I, II, and III were observed in both groups. Results. Only the rate of pneumonectomy was significantly higher in younger patients (41% versus 22%, p = 0.002). The overall operative mortality rate in group 1 was 2.2% and 2.6% after pneumonectomy. In group 2 the overall m ortality rate was 2.5% and 3.8% after pneumonectomy. Advanced age did not a ffect operative mortality. The adjusted (tumor-related) survival rate at 5 years was 56% in group 1 and 53% in group 2 (p = 0.93). The adjusted surviv al rate for patients with stage I was 61% in group 1 and 65% in group 2 (p = 0.21), and for stage IIIa 39% in group 1 and 48% in group 2 (p = 0.43). T he adjusted 5-year survival rate was 56% in group 1 and 59% in group 2 for squamous cell carcinoma (p = 0.53) and 49% in group 1 and 42% in group 2 fo r adenocarcinoma (p = 0.76). Conclusions. Perioperative risk and midterm survival were similar in younge r and older patients after surgical resection of bronchogenic carcinoma. We believe that this result is because surgical candidates constitute already a highly selected group of patients. From these data it is not possible to conclude that biologic behavior of lung cancer is more aggressive in young er patients.